{"id":12461,"date":"2026-07-23T23:18:33","date_gmt":"2026-07-24T02:18:33","guid":{"rendered":"https:\/\/convergencia.tech\/inicio\/?p=12461"},"modified":"2026-07-23T23:18:34","modified_gmt":"2026-07-24T02:18:34","slug":"una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b","status":"publish","type":"post","link":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/","title":{"rendered":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><code>Precision Biosciences report\u00f3 los primeros resultados cl\u00ednicos de PBGENE-HBV, una terapia de edici\u00f3n g\u00e9nica in vivo basada en su plataforma ARCUS, que logr\u00f3 evidencia directa de eliminaci\u00f3n e inactivaci\u00f3n del ADNccc del virus de la hepatitis B, el reservorio viral que sostiene la infecci\u00f3n cr\u00f3nica en el h\u00edgado y que hasta ahora ning\u00fan tratamiento disponible pod\u00eda erradicar de forma definitiva.<\/code><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><code>Biopsias hep\u00e1ticas de los pacientes tratados mostraron una reducci\u00f3n de los transcriptos de ADNccc, mientras que la totalidad de los pacientes evaluables perdi\u00f3 los niveles detectables de pgRNA, un marcador clave de replicaci\u00f3n viral activa. A diferencia de los tratamientos antivirales actuales para la hepatitis B, que logran suprimir la replicaci\u00f3n del virus pero deben mantenerse de por vida porque no eliminan el reservorio viral latente en el n\u00facleo de las c\u00e9lulas hep\u00e1ticas, la plataforma ARCUS de Precision Biosciences fue dise\u00f1ada espec\u00edficamente para cortar y desactivar ese ADN viral remanente de forma dirigida.<\/code><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><code>Para la industria de la biotecnolog\u00eda, este resultado temprano \u2014aunque todav\u00eda preliminar\u2014 representa una prueba de concepto significativa: la hepatitis B cr\u00f3nica afecta a cientos de millones de personas en el mundo, y la ausencia de una cura definitiva ha sido durante d\u00e9cadas uno de los mayores desaf\u00edos no resueltos de la hepatolog\u00eda. Que una terapia de edici\u00f3n g\u00e9nica in vivo logre evidencia cl\u00ednica de eliminaci\u00f3n del reservorio viral abre una v\u00eda de desarrollo que distintas compa\u00f1\u00edas de edici\u00f3n gen\u00e9tica vienen persiguiendo en paralelo, con distintas plataformas de enzimas y sistemas de entrega.<\/code><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><code>Para los pacientes, la perspectiva de una terapia potencialmente curativa y de dosis finita \u2014en lugar de un tratamiento antiviral de por vida\u2014 cambiar\u00eda de forma radical el manejo cl\u00ednico de la enfermedad, aunque todav\u00eda restan etapas regulatorias y cl\u00ednicas extensas antes de que un tratamiento as\u00ed llegue a estar disponible de forma masiva. El caso tambi\u00e9n reabre el debate de fondo sobre los costos y el acceso equitativo a terapias g\u00e9nicas curativas, que hasta ahora han tendido a ser extremadamente costosas en su lanzamiento comercial.<\/code><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><code>Fuentes al pie:<\/code><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><code>CRISPR Medicine News: https:\/\/crisprmedicinenews.com\/news\/cmn-weekly-26-june-2026-your-weekly-crispr-medicine-news\/<\/code><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Precision Biosciences report\u00f3 los primeros resultados cl\u00ednicos de PBGENE-HBV, una terapia de edici\u00f3n g\u00e9nica in vivo basada en su plataforma ARCUS, que logr\u00f3 evidencia directa de eliminaci\u00f3n e inactivaci\u00f3n del ADNccc del virus de la hepatitis B, el reservorio viral que sostiene la infecci\u00f3n cr\u00f3nica en el h\u00edgado y que hasta ahora ning\u00fan tratamiento disponible [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":12462,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-12461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B - Convergencia.tech<\/title>\n<meta name=\"description\" content=\"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B - Convergencia.tech\" \/>\n<meta property=\"og:description\" content=\"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B\" \/>\n<meta property=\"og:url\" content=\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/\" \/>\n<meta property=\"og:site_name\" content=\"Convergencia.tech\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-24T02:18:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-24T02:18:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1672\" \/>\n\t<meta property=\"og:image:height\" content=\"941\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Claudio R Parrinello\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Claudio R Parrinello\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/\",\"url\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/\",\"name\":\"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B - Convergencia.tech\",\"isPartOf\":{\"@id\":\"https:\/\/convergencia.tech\/inicio\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png\",\"datePublished\":\"2026-07-24T02:18:33+00:00\",\"dateModified\":\"2026-07-24T02:18:34+00:00\",\"author\":{\"@id\":\"https:\/\/convergencia.tech\/inicio\/#\/schema\/person\/e5fe6aa8f1c43ac4a89cbdff073f62d4\"},\"description\":\"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B\",\"breadcrumb\":{\"@id\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#primaryimage\",\"url\":\"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png\",\"contentUrl\":\"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png\",\"width\":1672,\"height\":941},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/convergencia.tech\/inicio\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/convergencia.tech\/inicio\/#website\",\"url\":\"https:\/\/convergencia.tech\/inicio\/\",\"name\":\"Convergencia.tech\",\"description\":\"Convergencia.tech\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/convergencia.tech\/inicio\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/convergencia.tech\/inicio\/#\/schema\/person\/e5fe6aa8f1c43ac4a89cbdff073f62d4\",\"name\":\"Claudio R Parrinello\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/convergencia.tech\/inicio\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4bf26232b2090e32e55cf27d62bd64c1bc43df22f09309d12add5fb6b68e7182?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/4bf26232b2090e32e55cf27d62bd64c1bc43df22f09309d12add5fb6b68e7182?s=96&d=mm&r=g\",\"caption\":\"Claudio R Parrinello\"},\"url\":\"https:\/\/convergencia.tech\/inicio\/author\/c2421210\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B - Convergencia.tech","description":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/","og_locale":"es_ES","og_type":"article","og_title":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B - Convergencia.tech","og_description":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B","og_url":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/","og_site_name":"Convergencia.tech","article_published_time":"2026-07-24T02:18:33+00:00","article_modified_time":"2026-07-24T02:18:34+00:00","og_image":[{"width":1672,"height":941,"url":"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png","type":"image\/png"}],"author":"Claudio R Parrinello","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"Claudio R Parrinello","Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/","url":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/","name":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B - Convergencia.tech","isPartOf":{"@id":"https:\/\/convergencia.tech\/inicio\/#website"},"primaryImageOfPage":{"@id":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#primaryimage"},"image":{"@id":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#primaryimage"},"thumbnailUrl":"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png","datePublished":"2026-07-24T02:18:33+00:00","dateModified":"2026-07-24T02:18:34+00:00","author":{"@id":"https:\/\/convergencia.tech\/inicio\/#\/schema\/person\/e5fe6aa8f1c43ac4a89cbdff073f62d4"},"description":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B","breadcrumb":{"@id":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#primaryimage","url":"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png","contentUrl":"https:\/\/convergencia.tech\/inicio\/wp-content\/uploads\/2026\/07\/ChatGPT-Image-23-jul-2026-23_17_38.png","width":1672,"height":941},{"@type":"BreadcrumbList","@id":"https:\/\/convergencia.tech\/inicio\/una-terapia-genica-en-fase-clinica-logra-eliminar-el-reservorio-del-virus-de-la-hepatitis-b\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/convergencia.tech\/inicio\/"},{"@type":"ListItem","position":2,"name":"Una terapia g\u00e9nica en fase cl\u00ednica logra eliminar el reservorio del virus de la hepatitis B"}]},{"@type":"WebSite","@id":"https:\/\/convergencia.tech\/inicio\/#website","url":"https:\/\/convergencia.tech\/inicio\/","name":"Convergencia.tech","description":"Convergencia.tech","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/convergencia.tech\/inicio\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Person","@id":"https:\/\/convergencia.tech\/inicio\/#\/schema\/person\/e5fe6aa8f1c43ac4a89cbdff073f62d4","name":"Claudio R Parrinello","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/convergencia.tech\/inicio\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/4bf26232b2090e32e55cf27d62bd64c1bc43df22f09309d12add5fb6b68e7182?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4bf26232b2090e32e55cf27d62bd64c1bc43df22f09309d12add5fb6b68e7182?s=96&d=mm&r=g","caption":"Claudio R Parrinello"},"url":"https:\/\/convergencia.tech\/inicio\/author\/c2421210\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/posts\/12461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/comments?post=12461"}],"version-history":[{"count":2,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/posts\/12461\/revisions"}],"predecessor-version":[{"id":12464,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/posts\/12461\/revisions\/12464"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/media\/12462"}],"wp:attachment":[{"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/media?parent=12461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/categories?post=12461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/convergencia.tech\/inicio\/wp-json\/wp\/v2\/tags?post=12461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}